The Tasmanian Atlantic salmon industry is facing increasing challenges due to the impacts of climate change, these pose significant threats to local industry as well as to global aquaculture. Sub-optimum water temperature and dissolved oxygen are the two major factors that negatively influence the growth, survival, and physiological responses of salmon. Research is needed to investigate the effects of both short- and long-term changes in temperature and oxygen on Atlantic salmon production biology. The research will also help us to compare the response generated under different conditions and provide insights to the Tasmanian salmon industry about climate ready measures to be taken to achieve sustainable production. In conclusion, the research planned for this PhD project will be providing critical knowledge of the effect of major environmental variables on Atlantic salmon cultured in Tasmania, which will be helpful to boost the salmon production in future.